Current Issue : January - March Volume : 2011 Issue Number : 1 Articles : 6 Articles
The literature is full of disputes, contradictions and confusions regarding acne. This disease is more prevailing among the young people and often associated with suicide and depression. Acne starts appearing after the onset of puberty and can extend up to 40 to 50 years of age. As far as pathogenesis of acne is concerned it is not fully understood up till now. The main key factors responsible for the development of acne are: An increased production of sebum, Hypercornification, Colonization of bacteria in pilosebaceous duct and Inflammation. Although inflammation is not directly associated with the development of acne but it can results as a consequence of other factors for example, propionibacterium acnes when colonized into the ducts it cause the production of pro inflammatory cytokines and other antigens which initiate various cellular as well as non- cellular immune responses ultimately lead to inflammation. Treatment of acne is very frustrating and involves an understanding of etiopathological factors. The aim of this review is to study the various factors responsible for acne, there contribution towards the pathogenesis of acne and acne therapy....
The hydro-distilled essential of the aerial parts of blue flowered ‘rosemary’ (Rosmarinus officinalis L.), grown in Kumaon region of western Himalaya was investigated in different seasons viz. spring, summer, rain, autumn and winter by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total 37 components accounting for 90.21%-94.72% of the oil were identified. The major components of the oils were α-pinene (13.41%-16.03%), camphor (12.54%-17.72%), 1,8-cineole (5.85%-11.18%), α-terpineol + borneol (13.32%-19.07%), verbenone (3.03%-6.54%), and bornyl acetate (0.60%-6.49%) in different seasons. The α-pinene, camphor, and 1, 8-cineole were observed to be higher in winter, spring, and autumn seasons, respectively...
Contact-allergic reactions to cosmetics may be delayed-type reactions such as allergic and photo-allergic contact dermatitis, and\r\nmore exceptionally also immediate-type reactions, that is, contact urticaria. Fragrances and preservative agents are the most\r\nimportant contact allergens, but reactions also occur to category-specific products such as hair dyes and other hair-care products,\r\nnail cosmetics, sunscreens, as well as to antioxidants, vehicles, emulsifiers, and, in fact, any possible cosmetic ingredient. Patch\r\nand prick testing to detect the respective culprits remains the golden standard for diagnosis, although additional tests might be\r\nuseful as well. Once the specific allergens are identified, the patients should be informed of which products can be safely used in\r\nthe future....
Acne is a common disease of the pilosebaceous units of the skin and topical therapy is recommended for the management of acne with comedolytic, anti-inflammatory agents, along with antimicrobials. However, topical application of these drugs leads to frequent adverse effects and also, there is an emergence of antibiotic resistance by Propionibacterium acnes. Furthermore, systemic antimicrobial usage has been causally associated with various adverse events. No simple recipe for the treatment can be provided. Treatment options vary with the stage and severity of the disease. So now a day�s physicians prefer the herboformulations containing Melaleuca alternifoli, Azadirachta indica, Curcuma longa, Piper nigrum, Aloe vera, Citrus bergamia, Santalum album, Rosa centifolia, Carica papaya etc. than the allopathic drugs due to less or no side effects. Perfect gel is herbal formulation contains 5% of Melaleuca alternifoli (Tea tree oil) and Perfect tablet is polyherbal formulations and contains extracts of Azadirachta indica,Curcuma longa, and Piper nigrum, and the study was conducted to evaluate the efficacy and safety of perfect face Gel, Perfect face tablets and both in the management of acne.\r\n\r\nIn this contest, the present work is carried out which includes Uncontrolled randomized, open labelled, multicentric Phase III clinical trial using oral Ayurvedic multicomponent preparations with or without use of Ayurvedic dermatological formulation in three different hospitals from 15 July 2009 to 15 Oct 2009. One hundred fifty three patients (n = 153) including 63 males and 90 females in the age group of 35-50 years were enrolled. Children below 18 years of age, patients with preexisting systemic disease necessitating long-term medications, genetic and endocrinal disorders and those who refused to give informed consent were excluded from the study. Pregnant and lactating women were also excluded from the study. A baseline history was obtained in order to determine the patient�s eligibility for enrolment in the trial. Thereafter all patients underwent a clinical examination and thorough skin examination was done the subjects are divided in to three groups. Group I received Perfect oral Tablet, Group II received dermatological gel (Perfect Face gel) and Group III received oral tablet and dermatological gel formula. Efficacy was assessed by the ability of perfect face gel and perfect face tablets to reduce the number of inflamed and non-inflamed lesions by using Leed�s counting method and Cardiff index method. The group III shows more 12% as compared to group II. It was concluded that group III having more significant effect on the inflamed lesion as compared to group I and II treatment....
In this study creams were formulated based on the anti-oxidant potential of herbal extracts and its evaluation. Selected plant parts are dried and extracted using 70% alcohol by maceration. All the extracts are tested for antioxidant activity by Lipid peroxidation. Quality evaluation of the anti-wrinkle product was assessed by using heating–cooling cycle’s method. No change of the physical properties was observed; the pH was in a proper range (approximately pH7). The quantity of gallic acid as marker of the crude extract and the product was analyzed by HPLC. The concenttration of gallic acid in crude extract and finished product was 9.676% w/w and 1.256% w/w respectively. All the formulations show good spreadability, no evidence of phase separation and good consistency during this study period. Stability parameters like visual appearance, nature, leakage and fragrance of the formulations showed that there was no significant variation for a period of six months. There is no sign of microbial growth after incubation period of 24hrs at 370C and it was comparable with the control. From the present study it can be concluded that it is possible to develop creams containing herbal extracts having antioxidant property and can be used as the provision of a barrier to protect skin....
Melasma is a common hypermelanotic disorder affecting the facial area which has a considerable psychological impact on the\npatient. Managing melasma is a difficult challenge that requires long-term treatment with a number of topical agents, such as\nrucinol and sophora-alpha. Aims.We aim to compare the combined treatment of skin needling and depigmenting serum with that\nusing depigmenting serum alone in the treatment of melasma, in order to evaluate the use of microneedles as a means to enhance\nthe drug�s transdermal penetration. Methods. Twenty patients were treated with combined skin needling and depigmenting serum\non one side of the face and with depigmenting serum alone on the other side. The outcome was evaluated periodically for up to\ntwo months using theMelasma Area Severity Index score and the Spectrocolorimeter X-Rite 968. Results. The side with combined\ntreatment (skin needling + depigmenting serum) presented a statistically significant reduction in MASI score and luminosity\nindex (L) levels compared to the side treated with depigmenting serum alone, and clinical symptoms were significantly improved.\nConclusions. Our study suggests the potential use of combining skin needling with rucinol and sophora-alpha compounds to\nachieve better results in melasma treatment compared to rucinol and sophora-alpha alone....
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